Researchers in the Department of Infectious Medicine of Peking Union Medical College Hospital have been the first in the world to report that after a long-term cocktail treatment, HIV patients who have been negative for HIV (HIV) in their blood still have high HIV in their tears. Viral load. The research results suggest that the lacrimal glands, tear fluid, and related tissues and organs are likely to be the new "bases" of the HIV virus. The research results were published in the AIDS Journal.
Leading this research is Professor Li Taisheng of Peking Union Medical College Hospital. He graduated from Guangzhou Zhongshan Medical University (now Sun Yat-sen University) in early years and is currently the director of the AIDS diagnosis and treatment center of the Department of Internal Medicine of Peking Union Medical College Hospital. In 1997, he first proposed a new theory of immune function reconstruction in AIDS patients. This scientific discovery has opened a new door of hope for the treatment of AIDS patients and has a milestone in the research of AIDS.
According to reports, in 2005, experts in the Department of Infectious Medicine and Ophthalmology of Peking Union Medical College Hospital first discovered that there was HIV viral load in the anterior aqueous humor of AIDS patients. Because of the unclear difference between aqueous humor and tears, some media reported that "HIV was found in tears" in the report that year. However, this false alarm led to new thinking from AIDS experts: After successful cocktail treatment, in the case of AIDS patients with negative blood HIV, is there HIV virus load in the tears? Along this line of thought, Li Taisheng et al. The first quantitative analysis of HIV viral load in the tears of AIDS patients in the world.
Li Taisheng et al. Selected 16 AIDS patients who had received cocktail therapy for a long time and were negative for HIV virus in peripheral blood as the study group. Two newly diagnosed but untreated and 3 patients who developed drug resistance after treatment were used as the control group. With the assistance of AIDS specialist nurses and the informed consent and cooperation of 21 patients, the researchers were very difficult to get more than 1 ml of tears from each patient, using internationally accepted viral load detection, polymerase chain reaction (PCR) Various methods were used to select 4 different gene sites for simultaneous detection. The results showed that there was no difference in the HIV viral load in the tears of the research group and the control group, which was 200 copies / ml ~ 20000 copies / ml, much higher than normal Value (below 50 copies / ml).
This finding suggests that in addition to CD4 positive T lymphocytes, macrophages and other HIV "repositories" that have been found, lacrimal glands, tear fluid, and related tissues and organs are likely to be new "bases" for HIV. HIV is very likely Infection occurs through tears. Li Taisheng reminded medical staff to strengthen protection and handle cautiously when conducting eye examinations or operations on HIV-positive patients.
Original summary:
Detection of HIV-1 viruses in tears of patients even nder long-term highly active antiretroviral therapy
To determine whether HIV-1 viruses exist in tears of patients under highly active antiretroviral therapy (HAART), a cross-sectional study was designed. All subjects who underwent long-term HAART with undetectable plasma viral load had detectable HIV-1 viral load in tears (n = 16), and had no difference from the control subjects (n = 5). Our data suggested that the lacrimal gland and / or other tear-associated tissues could be new reservoirs for HIV-1 and precautions should be taken when doing eye examinations.
About the Author:
Li Taisheng, male, chief physician, professor, director of infectious medicine, doctoral tutor, born in 1963, graduated from the medical department of Guangzhou Zhongshan Medical University in 1984, received a master's degree from Peking Union Medical College in 1990, and was in France from 1993 to 1999 He obtained a doctorate and started working in the internal medicine department of Peking Union Medical College Hospital in 1984. He is currently the deputy director of the Department of Internal Medicine, deputy director of the Department of Infectious Medicine and director of the AIDS diagnosis and treatment center of Peking Union Medical College Hospital. He served as the deputy leader of the AIDS clinical professional group of the Ministry of Health and the deputy leader of the clinical group of the AIDS expert advisory committee of the Ministry of Health, the standing member of the Infectious Diseases and Parasites Branch of the Chinese Medical Association and the head of the AIDS group, and the standing committee of the Tropical Diseases and Parasites Branch of the Chinese Medical Association , Is a famous infectious disease expert and AIDS expert.
During his master's degree study in China in 1990, an ELISA method was established to determine the serum G-CSF level. This discovery has been granted national patents and has been approved by the state for the diagnosis and differential diagnosis of clinical fever. Third prize. From 1993 to 1999, during his studies in France, he published several articles in "Science", "Natural Medicine", "Lancet" and other magazines. In 1997, he first proposed a new theory of immune function reconstruction in AIDS patients This scientific discovery has opened a new door of hope for the treatment of AIDS patients, and has a milestone in the research of AIDS. In 1998, he was rated as an excellent student studying in France by the Ministry of Education. He won the 1999 Excellent Foreign Doctor Award in France, the first Chinese to win the award, and Xinhua News Agency issued a national draft for this purpose. After returning to China in 1999, he established the Clinical Cell Immunology Laboratory in Peking Union Medical College Hospital, established the normal value of T cell immune function in Chinese normal people, and conducted pioneering research on the immune changes and immune function reconstruction of Chinese AIDS patients. First prize of the hospital's 2001 scientific research achievements. Since returning to China, he has made lectures on AIDS nearly 100 times in conferences and training courses, listened to tens of thousands of trainees, and trained a large number of key forces in the fight against AIDS for the country. Now he is responsible for a number of international and domestic scientific research projects including the EU and NIH HIV CIPRA projects and the national "Tenth Five-Year Plan". In 1998, he was awarded the "Excellent Foreign Physician Award-Victoria Hugo Award" by France, the first Chinese to receive the award. Li Taisheng studied and worked in France from October 1993 to January 1999. During this period, he worked with his French counterparts to make breakthroughs in the research of restoring the immune function of AIDS patients, and published many scientific journals such as "Science", "Natural Medicine", "Lancet", etc. An academic paper received high evaluation from the international medical community.
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