Formation of the concept of apoptosis and research on morphology (1972) Kerr et al. Published a paper in the British Journal of Cancer in 1972, proposing the concept of apoptosis (apotosis) for the first time. Announced the beginning of a real exploration of apoptosis. Kerr et al. Noted two different forms of cell death when studying liver ischemia. The first type is the disintegration of the cell membrane, the morphology of the organelles changes, and the lysosome disappears, that is, necrosis, while the second type is the integrity of the cell membrane, the morphology of the organelles, the shrinkage of the chromatin, and the fragmentation of the nuclear. The cell eventually divides itself into several bodies with intact outer membrane. Kerr used Greek expressions to describe this form of cell death, the noun apoptosis (apo: away, from; ptosis: falling) that describes the fall of leaves.
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