The reporter recently learned from the Wuxi Science and Technology Bureau that the scientific research personnel of Lanno Biotechnology Wuxi Co., Ltd. successfully implanted the gene of human recombinant seventh coagulation factor into the rabbit genome, and cultivated the transgenic rabbit containing the seventh coagulation factor. A large number of human-derived seventh coagulation factors are secreted in the milk. Once this result has passed the relevant risk assessment, it will be mass-produced and replace imported medicines used for the treatment of traumatic bleeding and common blood diseases.
The production of human-derived seventh coagulation factor is a cutting-edge biopharmaceutical technology in the world. At present, China ’s annual demand for the seventh coagulation factor is 300 grams, all of which depend on imports. The high price on the market is as high as 1.4 million US dollars per gram. He lost his life because he could n’t afford or could not afford medicine. In Europe and the United States, cattle and sheep are mainly used as carriers for extracting the seventh coagulation factor transgenic drugs. Compared with rabbits, the same output requires several times the reproduction cycle and is expensive.
Lannuo uses rabbits as a carrier, which not only guarantees the output, but also has a low cost. These seed rabbits are almost identical to ordinary rabbits in appearance. The recombinant human-derived seventh coagulation factor gene in their bodies can be passed on to the next generation of transgenic rabbits through reproduction. "At present, the third generation carrying this gene has been successfully bred through seed rabbits, with a success rate of 18%, far exceeding the 5% of international industrial production. Therefore, after being put into mass production, more Chinese people can buy it , A 'life-saving medicine' that can withstand traumatic bleeding, "said Du Fuliang, president of Lanno.
Tests by relevant state agencies have shown that the production of the seventh coagulation factor in the transgenic rabbits bred by Lanno Company is as high as 0.5 mg / ml. In Other words, as long as 100-150 genetically modified rabbits can meet the domestic demand for the seventh coagulation factor product every year. The research technology has reached the international advanced level.
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